Starving brain of glucose likely to trigger Alzhemier’s

December 25th, 2008

WASHINGTON - If the brain is gradually starved of glucose as one ages, then it is likely to trigger a biochemical process resulting in forms of Alzheimer’s disease.

A new study has found that when cardiovascular disease restricts blood flow in arteries to the brain, a process is launched that ultimately produces the sticky clumps of protein that appear to cause Alzheimer’s.

Robert Vassar, a professor of cell and molecular biology at the Northwestern University Feinberg School, who co-authored the study, discovered a key brain protein is altered when the brain has a deficient supply of energy.

The altered protein, called elF2alpha, increases the production of an enzyme that, in turn, flips a switch to produce the sticky protein clumps. Vassar worked with human and mice brains in his research.

‘This finding is significant because it suggests that improving blood flow to the brain might be an effective therapeutic approach to prevent or treat Alzheimer’s,’ said Vassar.

A simple preventive strategy people can follow to improve blood flow to the brain is getting exercise, reducing cholesterol and managing hypertension.

‘If people start early enough, maybe they can dodge the bullet,’ Vassar said. For people who already have symptoms, vasodilators, which increase blood flow, may help the delivery of oxygen and glucose to the brain, he added.

Vassar said it also is possible that drugs could be designed to block the elF2alpha protein that begins the formation of the protein clumps, known as amyloid plaques, said a Northwestern release. The study was published in Friday’s issue of Neuron.

An estimated 10 million baby boomers will develop Alzheimer’s in their lifetime, according to the Alzheimer’s Association. The disease usually begins after age 60, and risk rises with age.

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