Obesity seems to increase the risk of Renal Cell Cancer in women while in men a small hip circumference is associated with increased risk.
Dr. Tobias Pischon from the German Institute of Human Nutrition investigated body fat distribution (in relation to Renal Cell Cancer risk) in 348,550 men and women.
Waist and hip circumference both are significantly associated with an increased risk of Renal Cell Cancer, but these associations were no more significant after adjustment of body weight was done, indicating that fat distribution does not predict Renal Cell Cancer risk in women beyond adiposity in general.
Researchers have a notion that protection against Renal Cell Cancer associated with larger hip measurement in men may reflect larger muscle mass and consequently increased insulin sensitivity, or bigger subcutaneous fat depots in the lower body that protect the liver from fatty acid overload.
Adiposity increases levels of insulin and insulin-like growth factor 1, which are known to have carcinogenic effects. Obesity is also associated with hypertension and diabetes, two risk factors for Renal Cell Cancer.
Thus, increasing rate of obesity may be partly blamed for the rising rates of Renal Cell Cancer said Dr. Pischon.
Link [www.cancerpage.com/news/article.asp?id=9517]
Filed under Cancer, Health, Kidney, Obesity
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