HIV-1 Vaccine Enters Phase I Clinical Trial at National Institutes of Health (NIH)艾滋病毒- 1疫苗進入I期臨床試驗在美國國家衛生研究院（保健院）
GenVec, Inc. (Nasdaq: GNVC), announced today that the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has begun a Phase I clinical trial to test a novel vaccine known as Ad35HIV-EnvA to prevent HIV-1 infection. genvec公司（ NASDAQ ： gnvc ）今天宣布，該疫苗研究中心（ vrc ）國家過敏和傳染病（ niaid ）的一部分，美國國家衛生研究院（保健院） ，已開始I期臨床試驗，以測試一種新型疫苗稱為ad35hiv - enva ，以防止HIV - 1感染。
This adenovector-based vaccine was developed under a collaborative research and development agreement (CRADA) between GenVec and the VRC.這adenovector為基礎的疫苗的研製下，合作研究和開發協議（ crada ）之間的genvec和vrc 。
The two-part Phase I clinical study is designed to evaluate the safety, tolerability and immunogenicity of the Ad35-EnvA vaccine in comparison to and in combination with the Ad5-EnvA vaccine in prime-boost schedules.兩個部分的I期臨床研究設計的安全性，耐受性和免疫原性的ad35 - enva疫苗的比較，以及在組合與ad5 - enva疫苗在黃金刺激的時間表。
The first part of the study, a dose-escalation evaluation, will enroll 15 healthy adult volunteers.第一部分的研究，劑量升級的評價，將招收15名健康成人志願者。 Three groups of five subjects each will receive one intramuscular injection of the vaccine at three different doses.三組5科目，每個將獲得1肌內注射的疫苗在3個不同劑量。 Following vaccination of each dose group, an internal safety review will be conducted.以下接種疫苗，每個劑量組，一個內部的安全進行檢討。 The second phase of the study is designed to test prime-boost combinations of Ad5- and Ad35-based vaccines.第二階段的研究是旨在測試總理-升壓組合a d5和a d35為基礎的疫苗。
Additional information about GenVec is available at www.genvec.com.如需有關genvec可在www.genvec.com 。
SOURCE: GenVec, Inc.資料來源： genvec公司
Filed under提起下 AIDS艾滋病 , ， Health健康 |
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