HIV-1 Vaccine Enters Phase I Clinical Trial at National Institutes of Health (NIH)艾滋病毒- 1疫苗进入I期临床试验在美国国家卫生研究院（保健院）
GenVec, Inc. (Nasdaq: GNVC), announced today that the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has begun a Phase I clinical trial to test a novel vaccine known as Ad35HIV-EnvA to prevent HIV-1 infection. genvec公司（ NASDAQ ： gnvc ）今天宣布，该疫苗研究中心（ vrc ）国家过敏和传染病（ niaid ）的一部分，美国国家卫生研究院（保健院） ，已开始I期临床试验，以测试一种新型疫苗称为ad35hiv - enva ，以防止HIV - 1感染。
This adenovector-based vaccine was developed under a collaborative research and development agreement (CRADA) between GenVec and the VRC.这adenovector为基础的疫苗的研制下，合作研究和开发协议（ crada ）之间的genvec和vrc 。
The two-part Phase I clinical study is designed to evaluate the safety, tolerability and immunogenicity of the Ad35-EnvA vaccine in comparison to and in combination with the Ad5-EnvA vaccine in prime-boost schedules.两个部分的I期临床研究设计的安全性，耐受性和免疫原性的ad35 - enva疫苗的比较，以及在组合与ad5 - enva疫苗在黄金刺激的时间表。
The first part of the study, a dose-escalation evaluation, will enroll 15 healthy adult volunteers.第一部分的研究，剂量升级的评价，将招收15名健康成人志愿者。 Three groups of five subjects each will receive one intramuscular injection of the vaccine at three different doses.三组5科目，每个将获得1肌内注射的疫苗在3个不同剂量。 Following vaccination of each dose group, an internal safety review will be conducted.以下接种疫苗，每个剂量组，一个内部的安全进行检讨。 The second phase of the study is designed to test prime-boost combinations of Ad5- and Ad35-based vaccines.第二阶段的研究是旨在测试总理-升压组合a d5和a d35为基础的疫苗。
Additional information about GenVec is available at www.genvec.com.如需有关genvec可在www.genvec.com 。
SOURCE: GenVec, Inc.资料来源： genvec公司
Filed under提起下 AIDS艾滋病 , ， Health健康 |
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