Diabetic patients who are treated with Pioglitazone are found to have 75 percent increases in body weight, which occurs due to water retention.

Dr Ananda Basu at Mayo Clinic compared the effects of Pioglitazone and Glipzide for body composition and water content on 19 patients.

Pioglitazone caused an average increase in total body water of 2.4 L. This accounted for 75 percent of the patients’ average weight gain of 3.1 kg. There was no change in total body water content with glipizide.

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