Chromosome Responsible for Lung Cancer Found染色體負責肺癌發現
Three groups of scientists have independently identified two genetic variations in chromosome 15 as a major reason for developing lung cancer.三組科學家已經確定了兩個獨立的遺傳變異在15號染色體作為一個主要的原因，發展中國家的肺癌。 They however hold differing opinion as to whether the variation causes the disease directly or by increasing addiction to cigarettes.然而，他們持有不同的意見，至於是否有變異導致這種疾病的直接或通過增加成癮的香煙。
Their study is in sharp contrast to the popular notion that smoking is the major, if not the only reason behind lung cancer.他們的研究是形成鮮明對比的流行概念，即吸煙是主要的，如果不是唯一的背後的原因，肺癌。
The MD Anderson Cancer Center team lead by Dr. Christopher Amos, Ph.D.該MD安德森癌症中心隊，率先博士克里斯托弗阿莫斯，博士研究生 (studied 5,778 persons with lung cancer and 4,831 controls, who were matched by smoking status) and the team at International Agency for Research on Cancer in Lyons, France, lead by Paul Brennan, Ph.D. （研究了5778人，與肺癌和4831控制，誰獲得相應的吸煙狀況）和團隊在國際癌症研究機構在法國里昂，鉛由保羅布倫南，博士研究生 (4,502 cases and 7,377 controls) found at best a modest association with smoking behavior. （四五〇二案件和7377管制）發現最好的溫和協會與吸煙行為。
On the other hand Dr. Kari Stefansson, MD, of Iceland’s DeCODE Genetics, said he and his colleagues found a clear link with increased smoking and difficulty quitting, which in turn contributed to smoking-related diseases like lung cancer and peripheral artery disease .在另一方面博士卡里斯特凡松，海事處，冰島的解碼遺傳學說，他和他的同事發現了明確的聯繫與增加吸煙和戒菸的困難，這反過來又有助於與吸煙有關的疾病一樣， 肺癌和周圍動脈疾病 。
“The association is very solid, the P-values are vanishingly small, and the sample size that we are looking at was very large,” Dr. Stefansson said. “該協會是非常堅實， p值是vanishingly小，樣本大小，我們現正研究是非常大， ”博士斯特凡松說。 The associations with lung cancer and peripheral artery disease were significant at P=1.5×10-8 and P=1.4×10-7, respectively.該協會與肺癌和周圍動脈疾病有顯著在P = 1.5 × 10-8和P = 1.4 × 10-7 ，分別為。 They had a large sample size of 13, 945 smokers.他們有一個大樣本的大小13 ， 945吸煙。
What all researchers agree on is that a region on chromosome 15 contains genetic variants that are relatively common in the population and they are linked, directly or indirectly, to lung cancer.所有研究人員同意，就是一個地區對15號染色體包含的遺傳變異是相對常見的在人口與他們聯繫，直接或間接肺癌。
Having one copy of the variant increases the risk of disease by about 30% and having two copies increases the risk by about 80%, the researchers said.有一個副本變異的風險增大疾病的約30 ％ ，並有兩個副本的風險增大約80 ％ ，研究人員說。
Source:資料來源： Nature性質
Tags:標籤： Chromosome染色體 , ， lung cancer肺癌
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