Broccoli Works Better In Prostate Cancer Patients With GSTM1 Gene
A team of British researchers from the Institute of Food Research have found out that one or more serving of broccoli a week can prevent the risk of prostate cancer. The study finds that men who ate 400 g of broccoli per week over a 12-month period had significant changes in the actions of genes related to the development of cancer. Moreover a regular serving of the broccoli can lower the aggressive growth of the tumor in a patient of prostate cancer.
The researchers have noticed changes of the genes in the prostate gland before, during and after volunteers consumed either a broccoli-rich or pea-rich diet. After six months, researchers found that prostate genes in men who consumed a broccoli-rich diet had more changes than genes in men on the pea-rich.
The another factor of gene called GSTM1 works there. It is found that the broccoli-rich diet was even more pronounced in the men who had a gene known as GSTM1. Various studies have so far proved the people with this gene actually benefit more from eating broccoli than those who do not have this gene.
To describe, the researchers have randomly assigned to either a broccoli-rich or a pea-rich diet. After six months there were no differences in gene expression between glutathione S-transferase mu 1 (GSTM1) positive and null individuals on the pea-rich diet but significant differences between GSTM1 genotypes on the broccoli-rich diet, associated with transforming growth factor beta 1 (TGFâ1) and epidermal growth factor (EGF) signaling pathways. Comparison of biopsies obtained pre and post intervention revealed more changes in gene expression occurred in individuals on a broccoli-rich diet than in those on a pea-rich diet. While there were changes in androgen signaling, regardless of diet, men on the broccoli diet had additional changes to mRNA processing, and TGFâ1, EGF and insulin signaling.
Lead author of the study, professor Richard Mithen, said that such studies will enable them to provide much better dietary advice in which specific combinations of fruit and vegetable are likely to be particularly beneficial to a particular disease.
Source: ctv.ca
Filed under Cancer, Health, Prostrate
